PDRN Skin Rejuvenation

At LIVO, PDRN skin rejuvenation is offered as a complementary addition to select in-office treatments, and can also be provided as a standalone treatment. PDRN is one of the ingredients that has drawn significant attention in aesthetic medicine in recent years, and our team will walk you through how it may fit into your treatment plan during your consultation.

What PDRN is

PDRN (polydeoxyribonucleotide) is a naturally derived polymer fragment purified from salmon DNA, made up of nucleotides — the basic building blocks cells use to carry out their normal functions. In aesthetic use, PDRN is valued for its potential to support the skin's own repair and renewal processes, working with the skin's biology rather than against it.

Because of a possible connection between this ingredient and skin cell signaling pathways, and its potential benefits for skin texture, elasticity, and hydration, interest in PDRN has grown quickly across dermatology and aesthetic medicine.

Where PDRN skin rejuvenation can be used

PDRN skin rejuvenation is commonly used in three areas: the eye area, face, and neck, and can be offered as a standalone treatment or paired with other treatments. Which area and product are appropriate for you will be determined together during your consultation, based on an assessment of your skin, your goals, and your overall treatment plan.

PDRN · Eye Area

The skin around the eyes is relatively thin and sensitive, so treatment in this area is performed more gently and precisely.

Why clients choose it

• Eye-area skin that looks dry or tired
• Wanting to improve the elasticity and firmness of the eye area
• An interest in improving the look of fine lines
• Wanting to enhance the results of another eye-area treatment already underway

What can I expect after treatment?

Every client's skin responds differently, and your provider will set expectations specific to your situation during your consultation. In general, clients commonly report their eye-area skin looking more hydrated and elastic within one to two weeks following treatment, with an improved look of fine lines and a more refreshed overall appearance.

Because the results of PDRN skin rejuvenation build over a series of treatments, the eye area typically requires multiple sessions before a more noticeable overall change is observed — the effect of a single treatment varies by individual, and your provider will discuss a reasonable treatment schedule with you during your consultation.

PDRN · Face

The face is the most common area for PDRN skin rejuvenation, typically used to improve overall skin quality and condition.

Why clients choose it

• Seeking a more plump, elastic-looking complexion
• Support for skin texture, hydration, and overall condition
• An interest in improving the look of sensitivity or redness
• Wanting to enhance the results of another skin treatment already underway

What can I expect after treatment?

Every client's skin responds differently, and your provider will set expectations specific to your treatment combination during your consultation. In general, clients commonly report their facial skin looking and feeling more plump and elastic within one to two weeks following treatment, with a smoother appearance and improvement in the look of sensitivity or redness as the treated area settles.

Because the results of PDRN skin rejuvenation build over a series of treatments, a more noticeable overall change typically requires multiple sessions — the effect of a single treatment varies by individual, and your provider will discuss a reasonable treatment schedule with you during your consultation.

PDRN · Neck

The neck has fewer oil glands and tends to show laxity and lines more readily. When PDRN skin rejuvenation is used in this area, the focus is on supporting the skin's overall condition.

Why clients choose it

• Neck skin that looks dry or lax
• Wanting to improve the firmness and radiance of the neck
• Wanting to enhance the results of another neck treatment already underway
• Seeking an advanced, forward-looking option within their broader skincare routine

What can I expect after treatment?

Every client's skin responds differently, and your provider will set expectations specific to your situation during your consultation. In general, clients commonly report their neck skin looking firmer and more radiant within one to two weeks following treatment, with an improved overall feel.

Because the results of PDRN skin rejuvenation build over a series of treatments, the neck area typically requires multiple sessions before a more noticeable overall change is observed — the effect of a single treatment varies by individual, and your provider will discuss a reasonable treatment schedule with you during your consultation.

PDRN Aftercare: What to Know

Mild redness, swelling, bruising, or small bumps at the treated area are common in the hours following treatment and typically settle quickly. Most clients return to their normal routine the same day. The eye area is relatively sensitive, so reactions during recovery may be slightly more noticeable there, though they also tend to settle quickly.

Do's

• Keep the treated area clean and free from makeup for the first 24 hours
• Apply a broad-spectrum SPF daily to protect your skin as it recovers
• Follow any specific guidance your provider gives you for your treatment combination
• Stay hydrated and give your skin time to settle before judging results

Don'ts

• Avoid active retinoids, exfoliating acids, or other active skincare ingredients on the treated area for 24–48 hours
• Avoid direct sun exposure and tanning beds for at least a few days following treatment
• Avoid harsh cleansers, physical exfoliation, or massage on the treated area for 48–72 hours
• Avoid alcohol and smoking around the time of treatment, as both can affect how your skin recovers

If you experience anything beyond mild, expected sensitivity — such as significant swelling, pain, or a reaction that concerns you — contact LIVO right away.

A thoughtful plan begins with a consultation

PDRN skin rejuvenation is only offered following an in-person consultation with your LIVO provider. This is not a formality — it's how we determine whether PDRN skin rejuvenation is a good fit for you, which area is appropriate, and which product and approach make sense for your goals.

Your consultation will cover:

• The area you're considering (eye area, face, or neck), and how PDRN skin rejuvenation may support it
• Your skin history, sensitivities, and any known allergies (especially any history of fish or seafood allergy)
• The specific product LIVO recommends for you, and why
• What a realistic outcome looks like for your individual skin
• Medical history, medications, allergies, and treatment goals

No PDRN skin rejuvenation treatment is added to a treatment plan without this conversation taking place first. We want you to feel confident and fully informed before deciding whether it's right for you.

What to expect

Your provider will explain the full process, timing, and what you can expect afterward as part of your consultation — tailored to the specific area, product, and treatment combination recommended for you.

Preparing for your appointment

Before your appointment, tell us about any known allergies (especially any history of fish or seafood allergy), your current skincare routine, and any active skin conditions. Avoid active retinoids or exfoliating acids on the treatment area for 24–48 hours beforehand, unless your provider advises otherwise.

Frequently asked questions

References

• Polydeoxyribonucleotides as Emerging Therapeutics for Skin Diseases: Clinical Applications, Pharmacological Effects, Molecular Mechanisms, and Potential Modes of Action.
• U.S. Food and Drug Administration. Dermal Fillers Approved by the Center for Devices and Radiological Health.